Publications

  • Yesilkanal, Ali, and Marsha Rosner. “Targeting Raf Kinase Inhibitory Protein Regulation and Function.” Cancers 10.9 (2018): 306.
  • Skinner JJ, Wang S, Lee J, Ong C, Sommese R, Sivaramakrishnan S, Koelmel W, Hirschbeck M, Schindelin H, Kisker C, Lorenz K, Sosnick TR, Rosner MR. Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13453-13458. doi: 10.1073/pnas.1711543114. Epub 2017 Dec 5. PubMed PMID: 29208709; PubMed Central PMCID: PMC5754776.
  • Lorenz K, Rosner MR, Brand T, Schmitt JP. Raf kinase inhibitor protein: lessons of a better way for β-adrenergic receptor activation in the heart. J Physiol. 2017 Jun 15;595(12):4073-4087. doi: 10.1113/JP274064. Epub 2017 May 23. Review. PubMed PMID: 28444807; PubMed Central PMCID: PMC5471367.
  • Bainer R, Frankenberger C, Rabe D, An G, Gilad Y, Rosner MR. Gene expression in local stroma reflects breast tumor states and predicts patient outcome. Sci Rep. 2016 Dec 16;6:39240. doi: 10.1038/srep39240. PubMed PMID: 27982086; PubMed Central PMCID: PMC5159815.
  • Wang X, Chow CR, Ebine K, Lee J, Rosner MR, Pan T, Munshi HG. Interaction of tRNA with MEK2 in pancreatic cancer cells. Sci Rep. 2016 Jun 15;6:28260. doi: 10.1038/srep28260. PubMed PMID: 27301426; PubMed Central PMCID: PMC4908586.
  • Frankenberger C, Rabe D, Bainer R, Sankarasharma D, Chada K, Krausz T, Gilad Y, Becker L, Rosner MR. Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages. Cancer Res. 2015 Oct 1;75(19):4063-73. doi: 10.1158/0008-5472.CAN-14-3394. Epub 2015 Aug 3. PubMed PMID: 26238785; PubMed Central PMCID: PMC4592465.
  • Lee U, Skinner JJ, Reinitz J, Rosner MR, Kim EJ. Noise-Driven Phenotypic Heterogeneity with Finite Correlation Time in Clonal Populations. PLoS One. 2015 Jul 23;10(7):e0132397. doi: 10.1371/journal.pone.0132397. eCollection 2015. PubMed PMID: 26203903; PubMed Central PMCID: PMC4512695.
  • Skinner JJ, Rosner MR. RKIP structure drives its function: a three-state model for regulation of RKIP. Crit Rev Oncog. 2014;19(6):483-8. Review. PubMed PMID: 25597357; PubMed Central PMCID: PMC4311871.
  • Yesilkanal AE, Rosner MR. Raf kinase inhibitory protein (RKIP) as a metastasis suppressor: regulation of signaling networks in cancer. Crit Rev Oncog. 2014;19(6):447-54. Review. PubMed PMID: 25597354; PubMed Central PMCID: PMC4311870.
  • Lawlor PN, Kalisky T, Rosner R, Rosner MR, Kording KP. Conceptualizing cancer drugs as classifiers. PLoS One. 2014 Sep 23;9(9):e106444. doi: 10.1371/journal.pone.0106444. eCollection 2014. PubMed PMID: 25248130; PubMed Central PMCID: PMC4172566.
  • Lee J, Lee J, Farquhar KS, Yun J, Frankenberger CA, Bevilacqua E, Yeung K, Kim EJ, Balázsi G, Rosner MR. Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E364-73. doi: 10.1073/pnas.1304840111. Epub 2014 Jan 6. PubMed PMID: 24395801; PubMed Central PMCID: PMC3903259.
  • Lee U, Frankenberger C, Yun J, Bevilacqua E, Caldas C, Chin SF, Rueda OM, Reinitz J, Rosner MR. A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients. PLoS One. 2013 Dec 11;8(12):e82125. doi: 10.1371/journal.pone.0082125. eCollection 2013. PubMed PMID: 24349199; PubMed Central PMCID: PMC3859562.
  • Sun M, Song CX, Huang H, Frankenberger CA, Sankarasharma D, Gomes S, Chen P, Chen J, Chada KK, He C, Rosner MR. HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9920-5. doi: 10.1073/pnas.1305172110. Epub 2013 May 28. PubMed PMID: 23716660; PubMed Central PMCID: PMC3683728.
  • Zeng L, Ehrenreiter K, Menon J, Menard R, Kern F, Nakazawa Y, Bevilacqua E, Imamoto A, Baccarini M, Rosner MR. RKIP regulates MAP kinase signaling in cells with defective B-Raf activity. Cell Signal. 2013 May;25(5):1156-65. doi: 10.1016/j.cellsig.2013.02.005. Epub 2013 Feb 14. PubMed PMID: 23416466; PubMed Central PMCID: PMC3622756.
  • Menon J, Doebele RC, Gomes S, Bevilacqua E, Reindl KM, Rosner MR. A novel interplay between Rap1 and PKA regulates induction of angiogenesis in prostate cancer. PLoS One. 2012;7(11):e49893. doi: 10.1371/journal.pone.0049893. Epub 2012 Nov 15. PubMed PMID: 23166790; PubMed Central PMCID: PMC3499522.
  • Zhou DH, Lee J, Frankenberger C, Geslain R, Rosner M, Pan T. Anti-tumor effects of an engineered “killer” transfer RNA. Biochem Biophys Res Commun. 2012 Oct 12;427(1):148-53. doi: 10.1016/j.bbrc.2012.09.028. Epub 2012 Sep 16. PubMed PMID: 22989754.
  • Bevilacqua E, Frankenberger CA, Rosner MR. RKIP Suppresses Breast Cancer Metastasis to the Bone by Regulating Stroma-Associated Genes. Int J Breast Cancer. 2012;2012:124704. doi: 10.1155/2012/124704. Epub 2012 Feb 12. PubMed PMID: 22482058; PubMed Central PMCID: PMC3296187.
  • Yun J, Frankenberger CA, Kuo WL, Boelens MC, Eves EM, Cheng N, Liang H, Li WH, Ishwaran H, Minn AJ, Rosner MR. Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer. EMBO J. 2011 Aug 26;30(21):4500-14. doi: 10.1038/emboj.2011.312. PubMed PMID: 21873975; PubMed Central PMCID: PMC3230370.
  • Liu J, Kuo WL, Seiwert TY, Lingen M, Ciaccio MF, Jones RB, Rosner MR, Cohen EE. Effect of complementary pathway blockade on efficacy of combination enzastaurin and rapamycin. Head Neck. 2011 Dec;33(12):1774-82. doi: 10.1002/hed.21701. Epub 2011 Mar 24. PubMed PMID: 21438065.
  • Kuo WL, Liu J, Mauceri H, Vokes EE, Weichselbaum R, Rosner MR, Cohen EE. Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context. Mol Cancer Ther. 2010 Oct;9(10):2814-24. doi: 10.1158/1535-7163.MCT-10-0352. Epub 2010 Sep 28. PubMed PMID: 20876745; PubMed Central PMCID: PMC2953602.
  • Eves EM, Rosner MR. MAP kinase regulation of the mitotic spindle checkpoint. Methods Mol Biol. 2010;661:497-505. doi: 10.1007/978-1-60761-795-2_31. PubMed PMID: 20812004.
  • Shemon AN, Heil GL, Granovsky AE, Clark MM, McElheny D, Chimon A, Rosner MR, Koide S. Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands. PLoS One. 2010 May 5;5(5):e10479. doi: 10.1371/journal.pone.0010479. PubMed PMID: 20463977; PubMed Central PMCID: PMC2864760.
  • Pavon-Eternod M, Gomes S, Geslain R, Dai Q, Rosner MR, Pan T. tRNA over-expression in breast cancer and functional consequences. Nucleic Acids Res. 2009 Nov;37(21):7268-80. doi: 10.1093/nar/gkp787. PubMed PMID: 19783824; PubMed Central PMCID: PMC2790902.
  • Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR. A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis. Blood. 2009 Nov 12;114(20):4592-600. doi: 10.1182/blood-2009-04-217042. Epub 2009 Aug 26. PubMed PMID: 19710505; PubMed Central PMCID: PMC2777131.
  • Shemon AN, Eves EM, Clark MC, Heil G, Granovsky A, Zeng L, Imamoto A, Koide S, Rosner MR. Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration. PLoS One. 2009 Jun 24;4(6):e6028. doi: 10.1371/journal.pone.0006028. PubMed PMID: 19551145; PubMed Central PMCID: PMC2696091.
  • Dangi-Garimella S, Yun J, Eves EM, Newman M, Erkeland SJ, Hammond SM, Minn AJ, Rosner MR. Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7. EMBO J. 2009 Feb 18;28(4):347-58. doi: 10.1038/emboj.2008.294. Epub 2009 Jan 15. PubMed PMID: 19153603; PubMed Central PMCID: PMC2646152.
  • Cohen EE, Zhu H, Lingen MW, Martin LE, Kuo WL, Choi EA, Kocherginsky M, Parker JS, Chung CH, Rosner MR. A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle. Cancer Res. 2009 Jan 1;69(1):65-74. doi: 10.1158/0008-5472.CAN-08-0377. PubMed PMID: 19117988; PubMed Central PMCID: PMC2746005.
  • Granovsky AE, Clark MC, McElheny D, Heil G, Hong J, Liu X, Kim Y, Joachimiak G, Joachimiak A, Koide S, Rosner MR. Raf kinase inhibitory protein function is regulated via a flexible pocket and novel phosphorylation-dependent mechanism. Mol Cell Biol. 2009 Mar;29(5):1306-20. doi: 10.1128/MCB.01271-08. Epub 2008 Dec 22. PubMed PMID: 19103740; PubMed Central PMCID: PMC2643833.
  • Zeng L, Imamoto A, Rosner MR. Raf kinase inhibitory protein (RKIP): a physiological regulator and future therapeutic target. Expert Opin Ther Targets. 2008 Oct;12(10):1275-87. doi: 10.1517/14728222.12.10.1275 . Review. PubMed PMID: 18781826.
  • Granovsky AE, Rosner MR. Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor. Cell Res. 2008 Apr;18(4):452-7. doi: 10.1038/cr.2008.43. Review. PubMed PMID: 18379591.
  • Hong J, Doebele RC, Lingen MW, Quilliam LA, Tang WJ, Rosner MR. Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1. J Biol Chem. 2007 Jul 6;282(27):19781-7. Epub 2007 May 9. PubMed PMID: 17491018.
  • Rosner MR. MAP kinase meets mitosis: a role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation. Cell Div. 2007 Jan 10;2:1. PubMed PMID: 17214889; PubMed Central PMCID: PMC1785371.
  • Shen Y, Joachimiak A, Rosner MR, Tang WJ. Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature. 2006 Oct 19;443(7113):870-4. Epub 2006 Oct 11. PubMed PMID: 17051221; PubMed Central PMCID: PMC3366509.
  • Eves EM, Shapiro P, Naik K, Klein UR, Trakul N, Rosner MR. Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint. Mol Cell. 2006 Aug;23(4):561-74. PubMed PMID: 16916643; PubMed Central PMCID: PMC1626587.
  • Cohen EE, Lingen MW, Zhu B, Zhu H, Straza MW, Pierce C, Martin LE, Rosner MR. Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase. Cancer Res. 2006 Jun 15;66(12):6296-303. PubMed PMID: 16778206.
  • Li P, Kuo WL, Yousef M, Rosner MR, Tang WJ. The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition. Biochem Biophys Res Commun. 2006 May 19;343(4):1032-7. Epub 2006 Mar 22. PubMed PMID: 16574064.
  • Liu J, Yang D, Minemoto Y, Leitges M, Rosner MR, Lin A. NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell. 2006 Feb 17;21(4):467-80. PubMed PMID: 16483929.
  • Lin C, Franco B, Rosner MR. CDKL5/Stk9 kinase inactivation is associated with neuronal developmental disorders. Hum Mol Genet. 2005 Dec 15;14(24):3775-86. Epub 2005 Dec 5. PubMed PMID: 16330482.
  • Hong J, Beeler J, Zhukovskaya NL, He W, Tang WJ, Rosner MR. Anthrax edema factor potency depends on mode of cell entry. Biochem Biophys Res Commun. 2005 Sep 30;335(3):850-7. PubMed PMID: 16099427.
  • Trakul N, Menard RE, Schade GR, Qian Z, Rosner MR. Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation. J Biol Chem. 2005 Jul 1;280(26):24931-40. Epub 2005 May 10. PubMed PMID: 15886202.
  • Trakul N, Rosner MR. Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein. Cell Res. 2005 Jan;15(1):19-23. Review. PubMed PMID: 15686621.
  • Kuo WL, Duke CJ, Abe MK, Kaplan EL, Gomes S, Rosner MR. ERK7 expression and kinase activity is regulated by the ubiquitin-proteosome pathway. J Biol Chem. 2004 May 28;279(22):23073-81. Epub 2004 Mar 19. PubMed PMID: 15033983.
  • Corbit KC, Trakul N, Eves EM, Diaz B, Marshall M, Rosner MR. Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein. J Biol Chem. 2003 Apr 11;278(15):13061-8. Epub 2003 Jan 27. PubMed PMID: 12551925.
  • Tang F, Tang G, Xiang J, Dai Q, Rosner MR, Lin A. The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol. 2002 Dec;22(24):8571-9. PubMed PMID: 12446776; PubMed Central PMCID: PMC139858.
  • Page K, Li J, Corbit KC, Rumilla KM, Soh JW, Weinstein IB, Albanese C, Pestell RG, Rosner MR, Hershenson MB. Regulation of airway smooth muscle cyclin D1 transcription by protein kinase C-delta. Am J Respir Cell Mol Biol. 2002 Aug;27(2):204-13. PubMed PMID: 12151312.
  • Hong J, Yoshida K, Rosner MR. Characterization of a cysteine proteinase inhibitor induced during neuronal cell differentiation. J Neurochem. 2002 Jun;81(5):922-34. PubMed PMID: 12065604.
  • Abe MK, Saelzler MP, Espinosa R 3rd, Kahle KT, Hershenson MB, Le Beau MM, Rosner MR. ERK8, a new member of the mitogen-activated protein kinase family. J Biol Chem. 2002 May 10;277(19):16733-43. Epub 2002 Mar 1. PubMed PMID: 11875070.

 

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